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Roberto Male Goettingen, Germany: 2olgvfksw8z20; Share

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Research Category: Basic

Biological Expertise: Cell Biology, Molecular Biology, Neurobiology, Physiology

Current Research: I pursued my Ph.D. at the University of Illinois at Chicago (USA) focusing my attention in the neurosteroid biosynthesis and how stress can alter this biosynthesis and affect animal and human behaviors. Currently, I continue growing as a neuroscientist at the European Neuroscience Institute at Goettingen (Germany). My studies are oriented to understand the cognitive impairment associated with anxiety disorders and Alzheimer’s disease from an "epigenetic" point of view.

Laboratory Skills: Animal Handling, Behavioral Phenotyping, Immunoblotting, Immunostaining, Microscopy, RNA Extraction, RT-PCR

Career Stage: Junior Post-doc

University: University of Goettingen Medical School/Max Planck Society

Publications: Pinna G, Agis-Balboa RC, Pibiri F, Nelson M, Guidotti A, and Costa E. Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice. Neurochem Res
DOI 10.1007/s11064-008-9718-5

Agis-Balboa RC, Pinna G, Pibiri F, Kadriu B, Costa E, and Guidotti A. Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice. Proc Natl Acad Sci USA 104(47):18736-18741, 2007. (The report generated dozens of articles in U.S. news outlets, including the Washington Post and Science Daily , and dozens more in international news media. The UIC press release is available at ).

Chen Y, Kundakovic M, Agis-Balboa RC, Pinna G, and Grayson DR. Induction of the reelin promoter by retinoic acid is mediated by Sp1. J Neurochem. 103(2):650-665. 2007.

Veldic M, Kadriu B, Maloku E, Agis-Balboa RC, Guidotti A, Davis JM and Costa E. Epigenetic DNA-methyltransferase 1 (DNMT1) overexpression in telencephalic GABAergic neurons a novel neuropathological target to be addressed in schizophrenia and bipolar disorder treatment. Schizophr Res. 91(1-3):51-61. 2007.

Agis-Balboa RC, Pinna G, Zhubi A, Maloku E, Veldic M, Costa E, Guidotti A. Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc. Natl. Acad. Sci. USA 103(39):14602-14607. 2006.

Pinna G, Agis-Balboa RC, Zhubi A, Matsumoto K, Grayson DR, Costa E and Guidotti A: Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation. Proc. Natl. Acad. Sci. USA 103(11):4275-4280. 2006. (Covered by media: ; ; ; ; ).

Dong E, Agis-Balboa RC, Simonini MV, Grayson DR, Costa E, Guidotti A. Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia. Proc Natl Acad Sci USA. 102 (35):12578-12583, 2005.

Pinna G, Agis-Balboa RC, Doueiri MS, Guidotti A, Costa E. Brain neurosteroids in gender-related aggression induced by social isolation. Crit Rev Neurobiol. 16(1-2):75-82, 2004.

Languages Spoken (in order of fluency): Spanish, English, Galician and Portuguese

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